Novel odorant compositions

ABSTRACT

Novel odorants of the formulae:    (I)  &lt;IMAGE&gt;   and   (II)  &lt;IMAGE&gt; wherein R1 represents a hydrogen atom or a methyl group and R2 represents a C1-6 alkyl group and wherein one of the two additional bonds indicated by dots may be present.

This is a division of application Ser. No. 569,121 filed Apr. 17, 1975, now U.S. Pat. No. 4,010,213.

FIELD OF THE INVENTION

This invention relates to novel alcohols and aldehydes, and to novel odorant compositions containing them.

SUMMARY OF THE INVENTION

The novel odorants have the formulae I and II, supra.

The alcohols of formula I hereinbefore are manufactured by reacting an aldehyde of the general formula ##STR2## wherein R¹, R² and the dotted lines have the significance given earlier, with a metal-organic compound of the formula A--CH₃, wherein A represents an alkali metal or a grouping Hal--Mg-- in which Hal represents a chlorine, bromine or iodine atom, and hydrolysing the reaction product.

The aldehydes of formula II can be prepared according to methods known per se; for example, by a glycidic ester condensation according to Darzens-Erlenmeyer-Claisen from ketones of the general formula ##STR3## wherein R¹, R² and the dotted lines have the significance given earlier.

DESCRIPTION OF THE PREFERRED EMBODIMENTS

The reaction of an aldehyde of formula II with a metal-organic compound aforesaid and the hydrolysis of the reaction product can be carried out in accordance with methods known per se.

Preferred alcohols of formula I are:

3-methyl-5-(2,6,6-trimethyl-2cyclohexenyl)-4-penten-2-ol,

3-methyl-5-(2,5,6,6-tetramethyl-2-cyclohexenyl)-4-penten-2-ol,

3-methyl-5-(2,2,6-trimethylcyclohexyl)4-penten-2-ol,

3-methyl-5-(2,2-diemthyl-6-methylenecyclo-hexyl)-4-penten-2-ol and

3-ethyl-5-(2,6,6-trimethyl-2-cyclohexenyl)-4-penten-2-ol,

which can be manufactured according to the present process from the corresponding aldehydes, namely from:

2-methyl-4-(2,6,6-trimethyl-2-cyclohexenyl)-3-butenal,

2-methyl-4-(2,5,6,6-tetramethyl-2-cyclohexenyl)-3-butenal,

2-methyl-4-(2,2,6-trimethylcyclohexyl)-3-butenal,

2-methyl-4-(2,2,-dimethyl-6-methylenecyclohexyl)-3-butenal and

2-ethyl-4-(2,6,6-trimethyl-2-cyclohexenyl)-3-butenal.

The alcohols of formula I possess particular odorant properties, being characterised by an especially fine sandalwood note. Such an odorant note has hitherto been completely unknown in the ionone series (i.e. in compounds such as those of formula I). The alcohols of formula I can accordingly be used as odorants. Since sandalwood oil is a very valuable and indispensable ingredient in perfumery and is becoming increasingly scarce and thus inexpensive, there exists a great need for suitable substitutes. The alcohols provided by the present invention are, to a large extent, capable of replacing sandalwood oil in perfumery and cosmetics. They are suitable for the manufacture of perfume compositions and Eau de Cologne, to which they often impart a reasonable note in amounts of about 0.1-40 wt.%, and also for perfuming technical and cosmetic products of all kinds (e.g. soaps, solid and liquid detergents, bath additives, lotions, creams, powders, deodorants etc) in weight ratios of 1 part per million to about 6%; it being understood, however, that these amounts may be increased or decreased as desired.

It will accordingly be appreciated that the invention includes within its scope

a. an odorant composition which contains as an essential odour-imparting ingredient an alcohols of formula I hereinbefore, and

b. a method of imparting an odour to materials by applying thereto or incorporating therein an odour-imparting amount of an odorant composition as defined under (a) or of an alcohol of formula I hereinbefore.

The aldehyde starting materials of formula II are novel and also form part of the present invention. These aldehydes likewise possess odorant properties as well as aroma properties.

The aldehydes of formula II can be prepared according to methods know per se; for example, by a glycidic ester condensation according to Darzens-Erlenmeyer-Claisen from ketones of the general formula ##STR4## wherein R¹, R² and the dotted lines have the significance given earlier.

A ketone of formula III is condensed with a haloacetic acid ester in the presence of an alkaline condensation agent to give a glycidic ester, which is then converted into the free acid by careful hydrolysis and decarboxylated.

The aldehydes of formula II can also be prepared by reacting a ketone of formula III in a manner known per se [see J. Am. Soc. 84, 3782 (1962); Tetrahedron Letters, 1963 169 and J. Am. Soc. 87, 1353 (1965)] with a sulphur compound of the formula ##STR5## to give an epoxide of the general formula ##STR6## wherein R¹, R² and the dotted lines have the significance given earlier, and isomerising said epoxide by treatment with a weak Lewis acid such as lithium perchlorate in an aprotic solvent, preferably an ether such as tetrahydrofuran, dioxane or 1,2-dimethoxyethane.

The following Examples illustrate the present invention:

EXAMPLE 1

A mixture of 192 g of α-ionone, 165.4 g of ethyl chloroacetate, 500 mg of phenothiazine and 100 ml of pyridine is treated with 81 g of sodium methylate within 30 minutes at -10° C. to -15° C. with the exclusion of moisture and oxygen from the air. After the addition of 100 ml of absolute ether, the mixture is stirred for 4 hours at -5° C. and treated with 400 ml of 15% methanolic sodium hydroxide while cooling. The mixture is stirred for 1 hour at 10° C., cooled to -30° C. and adjusted to a pH of about 4 by the addition of 600 ml of glacial acetic acid. After warming to room temperature, 1 liter of water is added and the mixture stirred again for 15 minutes (CO₂ evolution). Extraction with hexane, washing the organic phase neutral, drying over anhydrous sodium sulphate and removal of the solvent under reduced pressure yields 190 g of a brown, liquid crude product which is subjected to fractional distillation in vacuo and produces 125 g of 2-methyl-4-(2,6,6-trimethyl-2-cyclohexenyl)-3-butenal; b.p..sub. 0.15 = 90° C.; n_(D) ²⁰ = 1.4880. Odour: woody, ionone-like, flowery.

EXAMPLE 2

A solution of methylmagnesium iodide, prepared from 11 g of magnesium shavings and 76 g of methyl iodide, in 700 ml of absolute ether is added dropwise at -10° C. under nitrogen to a solution of 62 g of 2-methyl-4-(2,6,6-trimethyl-2-cyclohexenyl)-3-butenal in 700 ml of ether. The mixture is stirred for 4 hours at 30° C. and then poured on to an excess of ice-cold ammonium chloride solution. The mixture is extracted with ether in the usual manner, the extract is washed neutral with water and dried over anhydrous sodium sulphate to give, after removal of the solvent, 66 g of a yellow, slightly viscous oil which, after distillation in vacuo, yields 52 g of 3-methyl-5-(2,6,6-trimethyl-2-cyclohexenyl)-4-penten-2-ol; b.p.₀.008 = 90°; n_(D) ²⁰ = 1.4890. This alcohol has a very fine, tenacious sandalwood odour.

EXAMPLE 3

In a manner analogous to that described in Examples 1 and 2, the following compounds were obtained:

2-Methyl-4-(2,5,6,6-tetramethyl-2-cyclohexenyl)-3-butenal; b.p.₀.005 = 85° C.;

IR (film): 2710, 1730, 1455, 1390/1380/1370, 1255, 985, 815 cm⁻¹.

Odour: flowery with slight fruity sub-note.

3-Methyl-5-(2,5,6,6-tetramethyl-2-cyclohexenyl)-4-penten-2-ol; b.p.₀.001 = 89° C.; n_(D) ²⁰ = 1.4920;

IR (film): 3380, 1455, 1390, 1380, 1365, 1215, 1090, 1000, 985, 940, 910, 810 cm⁻¹.

Odour: sandalwood-like.

2-Ethyl-4-(2,6,6-trimethyl-2-cyclohexenyl)-3-butenal

IR (film): 2700, 1730, 1455, 1385, 1365, 980, 830 cm⁻¹.

Odour: sandalwood-like, fig-like, reminiscent of ionone.

3-Ethyl-5-(2,6,6-trimethyl-2-cyclohexenyl)-4-penten-2-ol; b.p.₀.08 = 82° C.; n_(D) ²⁰ = 1.4929;

IR (film): 3350, 1460, 1385, 1370, 980 cm⁻¹.

Odour: sandela, sandalwood-like.

3-Methyl-5-(2,2,6-trimethylcyclohexyl)-4-penten-2-ol; b.p.₀.001 = 63° C.; n_(D) ²⁰ = 1.4810;

IR (film): 3450, 1450, 1380, 1370, 1360, 1085, 980, 930, 920, 900 cm⁻¹.

Odour: new, increased sandalwood note, flowery.

3-Methyl-5-(2,2-dimethyl-6-methylenecyclohexyl)-4-penten-2-ol;

IR (film): 3450, 1642, 1450, 1380, 1360, 1080, 980, 935, 925, 885 cm⁻¹.

Odour: mellow, clinging sandalwood note.

EXAMPLE 4

1.3 g of a 55-60% sodium hydride paste are freed from paraffin oil with pentane and then suspended in 50 ml of dry dimethyl sulphoxide. After stirring for 1 hour at 70° C. there is obtained a clear solution to which, after cooling to room temperature, 30 ml of dry tetrahydrofuran are added. The mixture is cooled to 0° C. and successively treated, each time over a period of 5 minutes, with a solution of 6.1 g of trimethylsulphonium iodide in 30 ml of dimethyl sulphoxide and 4.8 g of α-ionone in 10 ml of dimethyl sulphoxide. The resulting mixture is stirred for 15 minutes at 0° C. and for 75 minutes at 35° C. For the working-up, the mixture is treated with ice-cold ammonium chloride solution and extracted with hexane. The extract is washed neutral, dried and concentrated to yield 4.8 g of a yellow oil from which, by vacuum distillation, there are obtained 4.0 g of 2-methyl-1,2-oxido-4-(2,6,6-trimethyl-2-cyclohexenyl)-3-butene; b.p.₀.005 = 80° C.

IR (film): 1450, 1380, 1360, 1295, 1202, 1130, 1070, 1060, 980, 965, 905, 895, 820, 808, 775, 740 cm⁻¹.

EXAMPLE 5

3.1 g of 2-methyl-1,2-oxido-4-(2,6,6-trimethyl-2-cyclohexenyl)-3-butene and 1.65 g of lithium perchlorate are stirred in 30 ml of dry 1,2-dimethoxyethane at 90° C. for 60 minutes. The yellow solution is diluted with ether, washed with water, dried and concentrated under reduced pressure. There are obtained 3.1 g of 2-methyl-4-(2,6,6-trimethyl-2-cyclohexenyl)-3-butenal; b.p.₀.15 = 90° C.; n_(D) ²⁰ = 1.4880.

EXAMPLE 6

In a manner analogous to that described in Examples 4 and 5 the following compounds were obtained:

2-Methyl-4-(2,2,6-trimethylcyclohexyl)-3-butenal;

IR (film): 2730, 1730, 1455, 1385, 1375, 1365, 975 cm⁻¹.

Odour: camphorous, green, fresh, flowery, slightly woody.

2-Methyl-4-(2,2-dimethyl-6-methylenecyclohexyl)-3-butenal;

IR (film): 2740, 1730, 1645, 1455, 1385, 1365, 980, 970, 890 cm⁻¹.

Odour: woody, ionone-like, flowery.

The following Examples illustrate typical odorant compositions containing the alcohols of formula I or the aldehydes of formula II:

EXAMPLE A

Odorant composition having a rose-sandalwood note.

    ______________________________________                                                              Parts by weight                                           ______________________________________                                         Geranium resinoid      20                                                      Geranium oil           20                                                      Cinnamic alcohol ex Storax                                                                            50                                                      Geraniol savon         110                                                     Linalool               60                                                      Phenylethyl alcohol    80                                                      Rosacetol Givaudan     30                                                      Baccartol Givaudan     100                                                     p-tertbutylcyclohexyl acetate                                                                         130                                                     3-Methyl-5-(2,6,6-trimethyl-2-                                                 cyclohexenyl)-4-penten-2-ol                                                                           400                                                                            1000                                                    ______________________________________                                    

Compositions having the foregoing odorant note can be used for perfuming toilet soaps and shaving soaps or shaving creams.

                  Example B                                                        ______________________________________                                         Odorant composition    Parts by weight                                         ______________________________________                                         Basil oil *            20                                                      Calamus oil *          20                                                      Vanillin *             10                                                      Lemon oil Italian      40                                                      Jasmin absolu reconstitution                                                                          40                                                      Lavender oil French    70                                                      Bergamotte oil         200                                                     Geranium oil           25                                                      Methylnonylacetaldehyde *                                                                             5                                                       p-Tertbutylcyclohexyl acetate                                                                         80                                                      γ-Methylionone   50                                                      Cedarwood oil American 50                                                      Vetiver oil Bourbon    20                                                      Patchouli oil          20                                                      Petitgrain oil French  50                                                      Heliotropin            25                                                      Coumarin               20                                                      Eugenol                20                                                      Isobutylsalicylate     30                                                      Oak-moss soluble       5                                                       Incense resinoid       10                                                      Musk ketone            10                                                      3-Methyl-5-(2,6,6-trimethyl-2-                                                 cyclohexenyl)-4-penten-2-ol                                                                           180                                                                            1000                                                    ______________________________________                                          * 10% in phthalic acid diethyl ester                                     

This odorant composition as an Eau de Cologne like note in the direction of "Eau de Santal", such as is very popular in men's lines. The odour is fresh and lively, being reasonably balanced with the sandalwood note.

                  Example C                                                        ______________________________________                                         Odorant composition    Parts by weight                                         ______________________________________                                         Bornyl acetate liquid  260                                                     Methyl 1-methylcyclododecyl ether                                                                     160                                                     α-Hexylcinnamaldehyde                                                                           120                                                     Benzyl acetate extra   100                                                     Incense odoresins      60                                                      Versalide              60                                                      Terpinol               60                                                      Rhodinol pure          60                                                      Citral                 40                                                      α-Methylbenzyl acetate                                                                          20                                                      2-Methyl-4-(2,6,6-trimethyl-2-                                                 cyclohexenyl)-3-butenal                                                                               60                                                                             1000                                                    ______________________________________                                    

The basic composition, which is reminiscent of the fragrance in the air of forests, takes on more volume by the addition of 2-methyl-4-(2,6,6-trimethyl-2-cyclohexenyl)-3-butenal; it becomes warmer and the slightly dominating note of citral becomes better enveloped.

                  Example D                                                        ______________________________________                                         Odorant composition    Parts by weight                                         ______________________________________                                         α-Ionone         400                                                     α-iso-Methylionone                                                                              200                                                     Phenylethyl alcohol    200                                                     Δ.sup.2 -Octynoic acid methyl ester                                      (10% in 95° alcohol)                                                                           40                                                      Rhodinol pure          20                                                      Geranium oil Bourbon   20                                                      Heliotropin            20                                                      ylang-ylang oil extra  20                                                      3-Methyl-5-(2,2,6-trimethylcyclo-                                              hexyl)-4-penten-2-ol   80                                                                             1000                                                    ______________________________________                                    

The basic composition (violet type) becomes flowery by the addition of 3-methyl-5-(2,2,6-trimethylcyclohexyl)-4-penten-2-ol and there is obtained a characteristic sandela note. 

What is claimed is:
 1. An odorant composition which contains as an odor - imparting ingredient an effective amount of an alcohol of the general formula ##STR7## wherein R¹ represents a hydrogen atom or a methyl group and R² represents a C₁₋₆ alkyl group and wherein one of the two additional bonds indicated by dots may be present and at least one other olfactorily desirable agent.
 2. An odorant composition in accordance with claim 1, wherein said alcohol is 3-methyl-5-(2,6,6-trimethyl-2-cyclohexenyl)-4-penten-2-ol.
 3. An odorant composition in accordance with claim 1, wherein said alcohol is 3-methyl-5-(2,5,6,6-tetramethyl-2-cyclohexenyl)-4-penten-2-ol.
 4. An odorant composition in accordance with claim 1, wherein said alcohol is 3-methyl-5-(2,2,6-trimethyl-cyclohexyl)-4-penten-2-ol.
 5. An odorant composition in accordance with claim 1, wherein said alcohol is 3-methyl-5-(2,2-dimethyl-6-methylenecyclohexyl)-4-penten-2-ol.
 6. An odorant composition in accordance with claim 1, wherein said alcohol is 3-ethyl-5-(2,6,6-trimethyl-2-cyclohexenyl)-4-penten-2-ol. 